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Orlin DJ, Munoz A, Berryman S, Semidey D, Murthy SE. Targeting Tmem63b and Piezo2 in C-fiber low threshold mechanoreceptor: limitation of Vglut3-IRES-Cre. BioRxiv posted July 31, 2025. doi: https://doi.org/10.1101/2025.07.26.666969.

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Halford J, Senatore AJ, Berryman S, Muñoz A, Semidey D, Doan RA, Coombs AM, Noimany B, Emberley K, Emery B, Monk KR, and Murthy SE. TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination. PNAS. 2025 Jul 29;122(30):e2507354122. Epub 2025 Jul 21.

 

Syrenne JT, Sonawane PJ, Murthy SE. Molecular architecture of TMEM63 mechanosensitive ion channels. Cell Calcium. 2023 Nov;115:102798. 

 

Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR. TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron. 2023 Oct 18;111(20):3195-3210.e7.

 

Murthy SE. Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons. J Gen Physiol. 2023 Jun 5;155(6). 

 

Murthy SE. Glycine-bound NMDA receptors are stretch-activated. Trends in Neuroscience 2022. S0166-2236(22)00158-8

 

Xie Q, Li J, Li H, Udeshi ND, Svinkina T, Orlin D, Kohani S, Guajardo R, Mani DR, Xu C, Li T, Han S, Wei W, Shuster SA, Luginbuhl DJ, Quake SR, Murthy SE, Ting AY, Carr SA, Luo L. Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code. Neuron. 2022 Jul 20;110(14):2299-2314.e8.

 

Jojoa-Cruz S, Saotome K, Tsui CCA, Lee WH, Sansom MSP, Murthy SE*, Patapoutian A*, Ward AB*. Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1. Nature Commun. 2022 Feb 14;13(1):850. 

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Procko C*, Murthy SE*, Keenan WT, Mousavi SAR, Dabi T, Coombs A, Procko E, Baird L, Patapoutian A, Chory J. Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants. Elife. 2021 Mar 16;10.  

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Murthy SE, Dubin AE, Whitwam T, Jojoa-Cruz S, Cahalan SM, Mousavi SAR, Ward AB, Patapoutian A.  OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels. Elife 2018. 7:e41844.

 

Jojoa-Cruz S*, Saotome K*, Murthy SE, Tsui CCA, Sansom MS, Patapoutian A, Ward AB. Cryo-EM structure of the mechanically activated ion channel OSCA1.2. Elife. 2018. 7:e41845.

 

Murthy SE, Loud MC, Daou I, Marshall KL, Schwaller F, Kühnemund J, Francisco AG, Keenan WT, Dubin AE, Lewin GR, Patapoutian A. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice. Science Transl. Med. 2018 10(462):eaat9897.

 

Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB. Structure of the mechanically activated ion channel Piezo1. Nature 2018. 554(7693):481-486.

 

Coste B*, Murthy SE*, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A. Piezo1 ion channel pore properties are dictated by C-terminal region. Nature Commun. 2015. 6:7223.